Colin Michie, Rizwana Zaidi, Jack Pottle


A case of symmetrical drug-related intertriginous and flexural exanthema (or SDRIFE) is described in a two year-old boy following treatment with oral ibuprofen.  The erythematous, purpuric, macular, symmetrical rash appeared within a day over his neck and trunk, covering both clavicles.  This was a rare reaction to ibuprofen in an unusual anatomical site.  SDRIFE is more typical the gluteal, thigh or intertriginious areas, hence its more colloquial name, ‘Baboon’ syndrome.


Ibuprofen, SDRIFE, baboon syndrome, drug hypersensitivity, child

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